Possible mechanisms of hypertension in endothelin-1 deficient mice
نویسندگان
چکیده
منابع مشابه
Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production.
BACKGROUND Telomere shortening has been related to vascular dysfunction and hypertension. In the present study, we analyzed the influence of telomerase deficiency and telomere shortening on arterial pressure (AP). METHODS AND RESULTS AP was evaluated in 6-month-old mice lacking the RNA component of the telomerase (terc-/-) at the first generation and third generation (G3). First generation an...
متن کاملExaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats.
Mechanisms by which endothelin (ET)-1 mediates chronic pulmonary hypertension remain incompletely understood. Although activation of the ET type A (ET(A)) receptor causes vasoconstriction, stimulation of ET type B (ET(B)) receptors can elicit vasodilation or vasoconstriction. We hypothesized that the ET(B) receptor attenuates the development of hypoxic pulmonary hypertension and studied a genet...
متن کاملRole of endothelin-1 in hypertension.
Endothelin-1 (ET-1) was first characterized as a potent vasoconstrictor and is overexpressed in the vasculature in different models of hypertension, such as deoxycorticosterone acetate-salt rats, Dahl salt-sensitive rats, and stroke-prone spontaneously hypertensive rats. Moreover, patients with moderate to severe hypertension present increased vascular levels of prepro-ET-1 mRNA. In addition to...
متن کاملRole of Endothelin-1 in Clinical Hypertension
Hypertension is the most common risk factor worldwide for cardiovascular morbidity and mortality.1,2 Currently it is estimated that a quarter of the world’s adult population is hypertensive, and this number is projected to increase to 30% by 2025.1 Although, there exist a number of drug therapies for hypertension, blood pressure (BP) control to target is still only achieved in 30% of patients.3...
متن کاملHypertension in b-Adducin–Deficient Mice
Polymorphic variants of the cytoskeletal protein adducin have been associated with hypertension in humans and rats. However, the direct role of this protein in modulating arterial blood pressure has never been demonstrated. To assess the effect of b-adducin on blood pressure, a b-adducin–deficient mouse strain (2/2) was studied and compared with wild-type controls (1/1). Aortic blood pressure w...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1998
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)40324-7